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Aim. Describe the psychological distress and the psychosocial concerns during the third wave of the pandemic in oncological patients and family caregivers and analyze the evolution of these variables in cancer patients taking as references April and December of 2020. Method. The researchers developed a self-administered questionnaire. It was composed by items developed ad hoc to assess sociodemographic characteristics and social concerns and the Kessler K-6 scale to measure psychological distress. Results. The proportion of oncological patients and family caregivers who showed clinical levels of distress was higher than that the ones of non-oncological population during December 2020. Clinical distress was higher in oncological patients during the December 2020, compared to April levels. This increase was especially significant among women and younger patients in both assessment moments. The main social concerns at the third wave for oncological patients and family caregivers were: the fear of contracting COVID-19, restlessness and fear of the future, suspension of the social contacts, the absence of face-to-face contact and inactivity in the streets and shops. Conclusions. The results of this study highlight the need to provide the proper care to oncological patients and family caregivers due to the presence of socio-emotional needs, and to develop strategies that allow them to be covered from psychological impact of COVID-19.Copyright © 2023, Universidad Compultense Madrid. All rights reserved.
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Pulmonary embolism (PE) is common among hospitalized adults with SARS CoV-2 pneumonia. D-dimer (DD)>1 mug/mL has been found to be a severity risk factor. However, most of the studies are based on retrospective data and the real prevalence is unknown Objectives: To evaluate the prevalence of PE in patients with SARS CoV-2 pneumonia, regardless clinical suspicion. Demographic and laboratory data, comorbidities, and clinical outcomes were compared between patients with and without PE Methods: Single-center prospective study. All consecutive cases of SARS CoV-2 pneumonia with DD>1 mug/mL underwent computed tomography pulmonary angiography Results: 179 patients (64 (55-74 years), 65% male) were included. PE was diagnosed in 71 patients (39.7%), mostly with a peripheral location and low thrombotic load (Qanadli score 10%). We did not find disparity in PE prevalence between men and women, and between obese and not obese patients. There were no differences in the intensive care unit admission rate. Mortality rate was 8.5% in patients with PE vs. 3.7% in those without PE, but the differences were not significant. Patients with PE had more history of cardiovascular disease and required more fractional inspired oxygen. DD, platelet distribution width (PDW), neutrophil-lymphocyte ratio (NLR), DD-lactate dehydrogenase ratio (DD/LDH), and DD-ferritin ratio values were significantly higher among PE patients. ROC analysis showed that PDW and DD/LDH had the greatest area under the curve Conclusion(s): Patients with SARS CoV2 pneumonia and DD>1mug/mL presented a high prevalence of PE, regardless of clinical suspicion. PDW, NLR, DD/LDH and DD/Ferritin may help to identify patients with high risk of PE.
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In March 2020, a pandemic was declared by COVID-19 and the governments of the world implemented the quarantine. We start from the premise that everything would depend on the social representations of the pandemic, a variable that also impacted the economy on all its scales. In Venezuela on March 16, 2020, the government decreed a radical quarantine that was restructured to a method called 7+7. The article shows the multilevel collective action of the socio-institutional actors with emphasis on the Bolivar State, of national and international economic importance due to its border link with Brazil. The field work was carried out in the Caroni municipality between March 2020 - December 2021, with a real-time research approach on the processes of interactions between the actors involved and Information and Communication Technologies (ICT). As a result, the collective actions undertaken;between the levels of government and its institutions, the private sector and civil society were significant in containing the spread of the virus and maintaining the subsistence of the local economy. It is concluded that the 7+7 quarantine scheme and the actions at the local level resulting from the agreements between most segments of society were decisive. Finally, they will highlight the form and method for the management of information and communication that made it possible to clean up the norms, agreements, and functional rules in a pandemic in the midst of complex and confusing social representations
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INTRODUCTION: Cardiovascular compromise in coronavirus disease 2019 (COVID-19) does not necessarily present with the classic symptoms described in myocarditis. There is growing evidence demonstrating subclinical cardiovascular compromise in the context of the intense inflammation unleashed, the cytokine storm involved, the baseline prothrombotic state, and the consequent endothelial dysfunction. We set out to analyse whether Troponin-T (TT) and the amino-terminal fraction of pro-brain natriuretic peptide (NT-proBNP) determined at hospital admission, are related to mortality during the hospitalization of these patients. MATERIAL AND METHODS: Analytical, observational, retrospective cohort and cross-sectional study. It included subjects with COVID-19 hospitalized for moderate-severe illness, from 20/03/20 to 15/11/20. The TT and NT-proBNP obtained in the first 24 hours from admission were analysed. Altered TT was considered if ≥.014 ng/dl and altered NT-proBNP if ≥300 pg/ml. RESULTS: One hundred and eight subjects were included, 63.2% men, age 51.5 years (59-43), 28% were admitted to the Critical Unit and 25% died. The group with elevated TT presented higher mortality (OR = 3.1; 95%CI = 1.10-8.85; p = .02). The group with elevated NT-proBNP also show higher mortality (OR = 3.47; 95%CI = 1.21-9.97; p = .01). On multivariate analysis, only NT-proBNP ≥300 pg/ml remained an independent risk factor. CONCLUSIONS: NT-proBNP levels ≥300 pg/ml at admission in patients with moderate-severe COVID-19 were associated with higher mortality.
Subject(s)
COVID-19 , Natriuretic Peptide, Brain , Peptide Fragments , Troponin T , Biomarkers/blood , Brain , COVID-19/mortality , Cross-Sectional Studies , Female , Humans , Male , Middle Aged , Natriuretic Peptide, Brain/blood , Peptide Fragments/blood , Prognosis , Retrospective Studies , Troponin T/bloodABSTRACT
Background. Patients with severe SARS-CoV-2 infection are at high risk of complications due to the intensive care unit stay. Hospital-acquired infections (HAI) are one of the most common complication and cause of death in this group of patients, it is important to know the epidemiology and microbiology of this hospital-acquired infections in order to begin to the patients a proper empirical treatment. We describe the epidemiologic and microbiologic characteristics of HAI in patients with COVID-19 hospitalized at intensive care unit (ICU) in a tertiary level private hospital in Mexico City. Methods. From April to December 2020, data from all HAIs in patients with severe pneumonia due to SARS-CoV-2 infection with mechanical ventilation at ICU were obtained. The type of infection, microorganisms and antimicrobial susceptibility patterns were determined. Results. A total of 61 episodes of HAIs were obtained, the most common was ventilator associated pneumonia (VAP) in 52.4% (n=32) followed by urinary tract infection (UTI) 34.4%(n=21) and bloodstream infection (BSI) 9.84% (n=6). Only two episodes corresponded to C. difficile associated diarrhea. We identified 82 different microorganisms, the most frequent cause of VAP was P. aeruginosa 22% (10/45) followed by K. pneumoniae 20% (9/45);for UTI, E. coli 28.5% (6/21), and S. marcescens 19% (4/21);for BSI the most frequent microorganism was S. aureus 28.5 (2/7). Regarding the antimicrobial susceptibility patters the most common were Extended Spectrum Beta-Lactamase (ESBL) Gram-negative rods followed by Methicillinresistant Staphylococcus aureus. Conclusion. In patients with severe COVID-19 hospitalized in the ICU the most frequent HAIs were VAP and UTI caused by P. aeruginosa and E. coli respectively. ESBL enterobacteriaceae was the most common resistant pattern identifed in the bacterial isolations in our series.
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Purpose: Work-family conflict is an important topic which had an evolution, starting from a static definition, where work and family domains were divided, to a more dynamic and complex balance. COVID-19 has influenced society and created a significant distress among families and working activity, and this topic has been characterised by a major interest, considering some old definitions where this balance was considered problematic but not as an enriching opportunity. Design/methodology/approach: The authors used SCOPUS to find all records mentioning work-family conflict, by considering book, article and review, excluding conference paper and considering only records written in English language. After a duplicated and not pertinent record removal, the authors obtained a number of 675 records. The authors considered 437 records from SCOPUS to create a cluster map. Findings: Using SCOPUS and VOSviewer the authors have clustered 5 different areas, which are regrouped in next clusters considering keywords with most co-occurrence and significancy: Work-life balance and burnout gender cluster job stress and performance social and family support job satisfaction. Research limitations/implications: Cluster map is origined only by SCOPUS database. Originality/value: This work aims to find a state of art about this topic, creating hypothesis where this problem has been exacerbated by 2020 due to important society modifications created by COVID-19, where recent evolution of work-family balance has been complicated by papers which come back to consider this balance as problematic. © 2021, Tancredi Pascucci, Brizeida Hernàndez Sanchèz and Josè Carlos Sanchéz Garcìa.
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The coronavirus disease 2019 (COVID-19) caused by SARS-Cov- 2 virus represents public health emergency of international concern. The recent development of SARS-CoV-2 vaccines offer great hope to fight against this worldwide pandemic. However, there are many unknowns moving forward, like how long immunogenicity lasts or how many doses are required to immunize a person. High-quality serology is a key tool in understanding the immunity to viruses, and the relevance of protection. The measurement of specific COVID-19 antibodies can be used and currently very necessary to verify the effectiveness of the different vaccines in the population. Here, we present an optimized ELISA-based serology protocol that can be applied in serum and in capillary blood. Validation was performed using serum collected from 113 hospitalized patients in Principe de Asturias University Hospital. Ninety-eight of them were diagnosed with COVID19 by a positive rRT-PCR result and fifteen samples were negative in rRT-PCR. We used an indirect ELISA assay, using the receptor binding domain (RBD) of the recombinant spike protein of SARS-Cov-2 to cover the plate. In addition, all patients were tested by commercial ELISA to compare with our cheap immunoassay. Results show that our ELISA assay is suitable for capillary blood samples and has a sensibility significantly higher than commercial ELISA. This study demonstrates the validity of our cheap immunoassay for the measurement of specific IgG in the serum of patients, which allows the safe and economic testing of all currently vaccinated people to ensure immunity in the population and the efficacy of vaccination. Surprisingly our assay works on capillary blood samples, which facilitates the process of obtaining the sample and can be carried out quickly and safely by the patients themselves. Therefore, our cheap immunoassay may be useful to provide population-based data on SARS-CoV-2 seropositivity, infection and immunity generated by the vaccines.
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Viral infections have affected human health, causing critical pandemics and mortality worldwide. Viruses can also cause enormous economic problems for society globally. Bioactive compounds isolated from fungi (both edible and nonedible) have shown potential activity against viruses. In this review, we describe the fungal natural compounds that have exhibited capability to inhibit some human pathogenic viruses, such as human immunodeficiency virus, dengue virus, herpes simplex virus, bovine herpes virus, influenza virus, respiratory syndrome virus, hepatitis virus among others. We focused on the biosynthetic pathways of fungal bioactive compounds and addressed the current knowledge about their antiviral mechanisms of action and specific targets. Fungal bioactive compounds are able to inhibit viral reproduction, blocking viral penetration, replication or translation as well as integrase or protease action. Fungal compounds able to inhibit protease such as. ganodermatriol, ergosterol, terpenoids, ganoderic acid GS-2, ganoderiol, sterigmatocystin, emericellin, cordycepin, ergosterol peroxide, myristic acid among others, may have a significant value to society at present, as they may have the potential to treat severe viral respiratory infections. Fungi represent a potential natural source of bioactive molecules that can be exploited for treating viral infections, which represent one of the main causes of disease worldwide. However, extensive investigations on clinical trials are required for the introduction of new antiviral agents into the market. © 2021 Verein zur Forderung des Open Access Publizierens in den Quantenwissenschaften. All rights reserved.